• In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge Agelas dilatata, against Pseudomonas aeruginosa 

      Pech-Puch, Dawrin; Pérez Povedano, Mar Anabel; Martínez-Guitián, Marta; Lasarte-Monterrubio, Cristina; Vázquez-Ucha, Juan Carlos; Bou, Germán; Rodríguez, Jaime; Beceiro, Alejandro; Jiménez, Carlos (MDPI, 2020-06-23)
      [Abstract] The pyrrole-imidazoles, a group of alkaloids commonly found in marine sponges belonging to the genus Agelas, display a wide range of biological activities. Herein, we report the first chemical study of the ...
    • In-Depth Analysis of the Role of the Acinetobactin Cluster in the Virulence of Acinetobacter baumannii 

      Conde-Pérez, Kelly; Vázquez-Ucha, Juan Carlos; Álvarez-Fraga, Laura; Ageitos, Lucía; Rumbo-Feal, Soraya; Martínez-Guitián, Marta; Trigo Tasende, Noelia; Rodríguez, Jaime; Bou, Germán; Jiménez, Carlos; Beceiro, Alejandro; Poza, Margarita (Frontiers, 2021-10-05)
      [Abstract] Acinetobacter baumannii is a multidrug-resistant pathogen that represents a serious threat to global health. A. baumannii possesses a wide range of virulence factors that contribute to the bacterial pathogenicity. ...
    • Involvement of HisF in the persistence of Acinetobacter baumannii during a pneumonia infection 

      Martínez-Guitián, Marta; Vázquez-Ucha, Juan Carlos; Álvarez-Fraga, Laura; Conde-Pérez, Kelly; Lasarte-Monterrubio, Cristina; Vallejo, J. A.; Bou, Germán; Poza, Margarita; Beceiro, Alejandro (Frontiers, 2019)
      [Abstract] Acinetobacter baumannii is currently considered one of themost problematic nosocomial microorganisms. In the present work the hisF gene from the ATCC 17978 strain and the AbH12O-A2 clinical isolate of A. baumannii ...
    • Kpi, a Chaperone-Usher Pili System Associated with the Worldwide-Disseminated High-Risk Clone Klebsiella Pneumoniae ST-15 

      Gato, Eva; Vázquez-Ucha, Juan Carlos; Rumbo-Feal, Soraya; Álvarez-Fraga, Laura; Vallejo, J. A.; Martínez-Guitián, Marta; Beceiro, Alejandro; Ramos Vivas, Jose; Sola-Campoy, Pedro Juan; Pérez-Vázquez, María; Oteo, Jesús; Rodiño-Janeiro, Bruno Kotska; Romero, Antonio; Poza, Margarita; Bou, Germán; Pérez, Astrid (National Academy of Sciences, 2020-07-08)
      [Abstract] Control of infections caused by carbapenem-resistant Klebsiella pneumoniae continues to be challenging. The success of this pathogen is favored by its ability to acquire antimicrobial resistance and to spread ...
    • Marine Organisms from the Yucatan Peninsula (Mexico) as a Potential Natural Source of Antibacterial Compounds 

      Pech-Puch, Dawrin; Pérez Povedano, Mar Anabel; Gómez, Patricia; Martínez-Guitián, Marta; Lasarte-Monterrubio, Cristina; Vázquez-Ucha, Juan Carlos; Novoa Olmedo, María Lourdes; Guillén-Hernández, Sergio; Villegas-Hernández, Harold; Bou, Germán; Rodríguez, Jaime; Beceiro, Alejandro; Jiménez, Carlos (MDPI, 2020-07-18)
      [Abstract] A total of 51 sponges (Porifera) and 13 ascidians (Chordata) were collected on the coast of the Yucatan Peninsula (Mexico) and extracted with organic solvents. The resulting extracts were screened for antibacterial ...